Our focus is on reconstruction of injured tissues including nerves, tendons, fascia, blood vessels, complex wounds and scarring, involving cell-based therapies and tissue-engineering approaches including the use of novel materials and 3D printing. Plastic and reconstructive surgery at the University of Manchester consists of surgeons and scientists working side-by-side in the Blond McIndoe Laboratories. Others are seeking to apply human adult (musculoskeletal, neural and haematopoietic) and pluripotent (embryonic and induced pluripotent) stem cells to therapies in patients with disease and to produce in vitro disease models to generate novel repair-therapeutics.Ĭontact: Sue Kimber Plastic and reconstructive surgery Scientists in our division seek to understand new molecular pathways regulating pluripotent stem cells using ’omics technologies. The development of therapies using embryonic or adult stem cells requires a fundamental understanding of the developmental process. The clean room facilities can be found here.Ĭo-directors: Adrian Woolf Sue Kimber Stem cell biology ![]() It brings together biologists, material scientists, bioengineers and clinicians with an interest in regenerative medicine aiming to repair, replace or regenerate damaged tissues, using cell or gene therapy and tissue engineering. The Manchester Regenerative Medicine Network is a cross-faculty multidisciplinary network at The University of Manchester. Regulating inflammatory responses in tissue repair ĭisease modelling for drug and therapeutic development Ĭontact: Sue Kimber Manchester Regenerative Medicine Network Our internationally leading themes that address unmet clinical needs include:ĭeveloping stem cell gene therapies for inherited genetic diseases Our strengths span bioengineering, biomaterials and tissue engineering, stem cells, developmental biology, cell-matrix biology, inflammation, wound healing and cell/gene therapies. ![]() Regenerative medicine builds upon our understanding of the basic mechanisms in cell and developmental biology with the ultimate aim of translating this knowledge to improve the repair, replacement or regeneration of damaged tissues and organs following disease, injury or ageing. Our research uses state of the art, enabling technologies such as super-resolution imaging, electron microscopy, genomics, proteomics, genome editing, nanomedicine, cell and gene therapies, including engineering and materials solutions. The work is multidisciplinary and collaborative, involving research into many different organs and tissues. Our research ranges from the mechanisms underpinning cell interactions with matrix in tissues, to understanding tissue development, stem cell biology and regeneration, through to clinical application, developing engineered tissues and delivering novel cell and gene therapies for patient benefit. ![]() Members of the Division of Cell Matrix Biology and Regenerative Medicine address fundamental questions in regenerative medicine, stem cell biology and the role of extracellular matrix in the building and repair of tissues.
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